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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1999 1
2000 1
2001 2
2002 6
2003 7
2004 14
2005 15
2006 24
2007 20
2008 27
2009 32
2010 27
2011 44
2012 39
2013 46
2014 43
2015 50
2016 59
2017 48
2018 59
2019 57
2020 57
2021 57
2022 38
2023 28
2024 14

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695 results

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Page 1
Differences in manifestations of Marfan syndrome, Ehlers-Danlos syndrome, and Loeys-Dietz syndrome.
Meester JAN, Verstraeten A, Schepers D, Alaerts M, Van Laer L, Loeys BL. Meester JAN, et al. Ann Cardiothorac Surg. 2017 Nov;6(6):582-594. doi: 10.21037/acs.2017.11.03. Ann Cardiothorac Surg. 2017. PMID: 29270370 Free PMC article. Review.
Many different heritable connective tissue disorders (HCTD) have been described over the past decades. These syndromes often affect the connective tissue of various organ systems, including heart, blood vessels, skin, joints, bone, eyes, and lungs. ...
Many different heritable connective tissue disorders (HCTD) have been described over the past decades. These syndromes often a …
Exosomes derived from human adipose mesenchymal stem cells attenuate hypertrophic scar fibrosis by miR-192-5p/IL-17RA/Smad axis.
Li Y, Zhang J, Shi J, Liu K, Wang X, Jia Y, He T, Shen K, Wang Y, Liu J, Zhang W, Wang H, Zheng Z, Hu D. Li Y, et al. Stem Cell Res Ther. 2021 Mar 31;12(1):221. doi: 10.1186/s13287-021-02290-0. Stem Cell Res Ther. 2021. PMID: 33789737 Free PMC article.
RT-PCR, immunoblotting, immunofluorescence, and immunohistochemistry staining were used to evaluate the expression of IL-17RA, Col1, Col3, alpha-SMA, SIP1, and p-Smad2/p-Smad3 in HSFs stimulated with ADSC-Exo, miR-192-5p mimics, or inhibitors, IL-17RA siRNA and their negat …
RT-PCR, immunoblotting, immunofluorescence, and immunohistochemistry staining were used to evaluate the expression of IL-17RA, Col1, Col3, a …
SMAD2 and SMAD3 differentially regulate adiposity and the growth of subcutaneous white adipose tissue.
Kumari R, Irudayam MJ, Al Abdallah Q, Jones TL, Mims TS, Puchowicz MA, Pierre JF, Brown CW. Kumari R, et al. FASEB J. 2021 Dec;35(12):e22018. doi: 10.1096/fj.202101244R. FASEB J. 2021. PMID: 34731499
Adipose tissue is the primary site of energy storage, playing important roles in health. ...The direct contributions of Smad2 and Smad3 in adipose tissues, however, are unknown. Here, we sought to determine the primary effects of adipocyte-selective reduction of …
Adipose tissue is the primary site of energy storage, playing important roles in health. ...The direct contributions of Smad2 …
Immunolocalization of transforming growth factor-beta1, connective tissue growth factor, phosphorylated-SMAD2/3, and phosphorylated-ERK1/2 during mouse incisor development.
Li S, Pan Y. Li S, et al. Connect Tissue Res. 2019 May;60(3):265-273. doi: 10.1080/03008207.2018.1499730. Epub 2018 Oct 22. Connect Tissue Res. 2019. PMID: 29991285
BACKGROUND/AIMS: Connective tissue growth factor (CTGF) is a downstream mediator of transforming growth factor-beta 1 (TGF-beta(1)) and TGF-beta(1)-induced CTGF expression is regulated through SMAD and mitogen-activated protein kinase (MAPK) signaling pathways. ...P …
BACKGROUND/AIMS: Connective tissue growth factor (CTGF) is a downstream mediator of transforming growth factor-beta 1 (TGF-bet …
Apigenin inhibits fibrous scar formation after acute spinal cord injury through TGFβ/SMADs signaling pathway.
Jin Z, Tian L, Zhang Y, Zhang X, Kang J, Dong H, Huang N, Pan L, Ning B. Jin Z, et al. CNS Neurosci Ther. 2022 Nov;28(11):1883-1894. doi: 10.1111/cns.13929. Epub 2022 Jul 30. CNS Neurosci Ther. 2022. PMID: 35906830 Free PMC article.
Western blotting and qRT-PCR were used to detect the expression of fibrosis-related parameters in spinal cord tissue homogenates. NIH-3 T3 cells and mouse primary spinal cord fibroblasts, alpha-Smooth muscle actin (alpha-SMA), collagen 1, and fibronectin were used to evalu …
Western blotting and qRT-PCR were used to detect the expression of fibrosis-related parameters in spinal cord tissue homogenates. NIH …
Mineralocorticoid and SGK1-sensitive inflammation and tissue fibrosis.
Artunc F, Lang F. Artunc F, et al. Nephron Physiol. 2014;128(1-2):35-9. doi: 10.1159/000368267. Epub 2014 Nov 6. Nephron Physiol. 2014. PMID: 25377230 Free article. Review.
SGK1 upregulates the inflammatory transcription factor nuclear factor-kappaB, which in turn stimulates the expression of diverse inflammatory mediators including connective tissue growth factor. Moreover, SGK1 inhibits the degradation of the TGF-beta-dependent trans …
SGK1 upregulates the inflammatory transcription factor nuclear factor-kappaB, which in turn stimulates the expression of diverse inflammator …
HDAC5-mediated Smad7 silencing through MEF2A is critical for fibroblast activation and hypertrophic scar formation.
Gao Y, Liu Y, Zheng D, Ho C, Wen D, Sun J, Huang L, Liu Y, Li Q, Zhang Y. Gao Y, et al. Int J Biol Sci. 2022 Sep 11;18(15):5724-5739. doi: 10.7150/ijbs.76140. eCollection 2022. Int J Biol Sci. 2022. PMID: 36263180 Free PMC article.
HDAC5 knockdown (KD) significantly downregulated TGF-beta1 induced Smad2/3 phosphorylation and increased Smad7 expression. Meanwhile, Smad7 KD rescued the Smad2/3 phosphorylation downregulation and scar hyperplasia inhibition mediated by HDAC5 deficiency. ...
HDAC5 knockdown (KD) significantly downregulated TGF-beta1 induced Smad2/3 phosphorylation and increased Smad7 expression. Meanwhile, …
Differential expression of transforming growth factor-beta1, connective tissue growth factor, phosphorylated-SMAD2/3 and phosphorylated-ERK1/2 during mouse tooth development.
Li S, Pan Y. Li S, et al. J Mol Histol. 2017 Dec;48(5-6):347-355. doi: 10.1007/s10735-017-9733-4. Epub 2017 Aug 19. J Mol Histol. 2017. PMID: 28825193
Connective tissue growth factor (CTGF) is a downstream mediator of transforming growth factor-beta 1 (TGF-beta(1)) and TGF-beta(1)-induced CTGF expression is regulated through SMAD and mitogen-activated protein kinase (MAPK) signaling pathways. ...DPL was intensely …
Connective tissue growth factor (CTGF) is a downstream mediator of transforming growth factor-beta 1 (TGF-beta(1)) and TGF-bet …
Immunolocalization of connective tissue growth factor, transforming growth factor-beta1 and phosphorylated-SMAD2/3 during the postnatal tooth development and formation of junctional epithelium.
Li S, Pan Y. Li S, et al. Ann Anat. 2018 Mar;216:52-59. doi: 10.1016/j.aanat.2017.10.005. Epub 2017 Nov 22. Ann Anat. 2018. PMID: 29175126
Connective tissue growth factor (CTGF) is a downstream mediator of transforming growth factor-beta 1 (TGF-beta(1)) and TGF-beta(1)-induced CTGF expression is regulated through SMAD pathway. ...These data demonstrate that the expression of CTGF, TGF-beta(1) and p-SNA …
Connective tissue growth factor (CTGF) is a downstream mediator of transforming growth factor-beta 1 (TGF-beta(1)) and TGF-bet …
695 results